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Cipla non-sedating antihistamine TVC
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Results The data collection periods for the four drugs were May to August for cetirizine and loratadine, May to September for acrivastine, and March to August for fexofenadine. A number of publications that evaluated different NSAHs in increasing doses have clearly demonstrated that a higher proportion of patients previously uncontrolled exhibit significant improvements of their symptoms after going through this approach [ 6 ]. Chronic unremitting urticaria: Although psychomotor and sleep studies in healthy subjects in the laboratory may predict that an antihistamine does not cause drowsiness, the safety margin can be narrow enough to cause a central sedating effect during actual treatment. An alternative hypothesis would be a differential H1-receptor occupancy by free unbound H1 antihistamine [ 25 , 28 ]. Topical antihistamines give immediate relief, while mast cell stabilisers provide more long-term protection. Additionally, the prescribers are asked to indicate whether the drug has been stopped and, if so, the reason for this. Dose-response was not addressed by these investigators and could be very relevant. Conclusions Although the risk of sedation was low with all four drugs, fexofenadine and loratadine may be more appropriate for people working in safety critical jobs. Citation s: Drugs in R and D. Mattila MJ 1 , Paakkari I. Subjects Event data were obtained for a total of 43 patients. Introduction Antihistamines are often used to treat the symptoms of allergies such as seasonal and perennial allergic rhinitis and urticaria. Incidence densities were calculated for all of the events reported, to give an indication of which events were reported significantly more frequently in the first month of exposure. Sedating antihistamines are not needed for long-term itching, because glucocorticoids are indicated and more effective.
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